Issue 30, 2014

Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

Abstract

Two promising uncharged reactivators for inhibited human BChE and AChE have been described. These compounds show an ability to reactivate VX-inhibited BChE largely superior to those of known pyridinium aldoximes. Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE.

Graphical abstract: Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

Supplementary files

Article information

Article type
Communication
Submitted
22 Jan 2014
Accepted
11 Feb 2014
First published
19 Feb 2014

Chem. Commun., 2014,50, 3947-3950

Author version available

Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

J. Renou, M. Loiodice, M. Arboléas, R. Baati, L. Jean, F. Nachon and P. Renard, Chem. Commun., 2014, 50, 3947 DOI: 10.1039/C4CC00561A

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