Issue 25, 2014

A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis

Abstract

The synthesis of oxazolines and imidazolines was achieved by activation of isocyanides with water. Mechanistic studies show that the organosuperbase proazaphosphatrane is tolerant of water within the reaction medium, with a beneficial and cooperative effect being observed.

Graphical abstract: A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis

Supplementary files

Article information

Article type
Communication
Submitted
28 Dec 2013
Accepted
31 Jan 2014
First published
31 Jan 2014

Chem. Commun., 2014,50, 3288-3291

Author version available

A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis

M. A. Honey, Y. Yamashita and S. Kobayashi, Chem. Commun., 2014, 50, 3288 DOI: 10.1039/C3CC49808E

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