Issue 27, 2014
From the journal:

Chemical Communications

Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization†

Jia Zheng,a   Min Zhang,a   Liangbin Huang,a   Xiaohan Hu,a   Wanqing Wu,a   Huawen Huanga  and  Huangfeng Jiang*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China
E-mail: jianghf@scut.edu.cn
Fax: +86 20-87112906
Tel: +86 20-87112906

Abstract

A novel Pd-catalyzed/Cu-mediated oxidative cyclization has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C–N and C–O bonds. In this protocol, four hydrogen atoms were removed and water was used as the oxygen atom source.

Graphical abstract: Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization

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Article information

DOI
https://doi.org/10.1039/C3CC49788G
Article type
Communication
Submitted
26 Dec 2013
Accepted
04 Feb 2014
First published
06 Feb 2014

Chem. Commun., 2014,50, 3609-3611

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Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization

J. Zheng, M. Zhang, L. Huang, X. Hu, W. Wu, H. Huang and H. Jiang, Chem. Commun., 2014, 50, 3609 DOI: 10.1039/C3CC49788G

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