Issue 22, 2014
From the journal:

Chemical Communications

Rational design of sulfoxide–phosphine ligands for Pd-catalyzed enantioselective allylic alkylation reactions†

Hong-Gang Cheng,ab   Bin Feng,ab   Li-Yan Chen,ab   Wei Guo,ab   Xiao-Ye Yu,ab   Liang-Qiu Lu,ab   Jia-Rong Chen*ab  and  Wen-Jing Xiao*ab  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology of Education, Ministry College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
E-mail: chenjiarong@mail.ccnu.edu.cn, wxiao@mail.ccnu.edu.cn
Fax: +86 27 67862041
Tel: +86 27 67862041

b Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), China

Abstract

A new type of chiral sulfoxide–phosphine ligands have been developed by a rational combination of two privileged scaffolds for Pd-catalyzed asymmetric allylic alkylation reactions. Under optimized conditions, generally high yields (up to 97%) and excellent enantioselectivities (up to >99% ee) were obtained.

Graphical abstract: Rational design of sulfoxide–phosphine ligands for Pd-catalyzed enantioselective allylic alkylation reactions

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Article information

DOI
https://doi.org/10.1039/C3CC49488H
Article type
Communication
Submitted
14 Dec 2013
Accepted
24 Jan 2014
First published
27 Jan 2014

Chem. Commun., 2014,50, 2873-2875

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Rational design of sulfoxide–phosphine ligands for Pd-catalyzed enantioselective allylic alkylation reactions

H. Cheng, B. Feng, L. Chen, W. Guo, X. Yu, L. Lu, J. Chen and W. Xiao, Chem. Commun., 2014, 50, 2873 DOI: 10.1039/C3CC49488H

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