Reversible Ag+-crosslinked DNA hydrogels

Weiwei Guo; Xiu-Juan Qi; Ron Orbach; Chun-Hua Lu; Lina Freage; Iris Mironi-Harpaz; Dror Seliktar; Huang-Hao Yang; Itamar Willner

doi:10.1039/C3CC49140D

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Reversible Ag⁺-crosslinked DNA hydrogels†

Weiwei Guo,‡^a Xiu-Juan Qi,‡^ab Ron Orbach,^a Chun-Hua Lu,^a Lina Freage,^a Iris Mironi-Harpaz,^c Dror Seliktar,^c Huang-Hao Yang^b and Itamar Willner*^a

Author affiliations

* Corresponding authors

^a The Institute of Chemistry, The Center for Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, Israel
E-mail: willnea@vms.huji.ac.il
Fax: +972-2-6527715
Tel: +972-2-6585272

^b The Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China

^c Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel

Abstract

DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag⁺-stimulated formation of cytosine–Ag⁺–cytosine complexes results in the crosslinking of the units to yield the hydrogels, while the cysteamine-induced elimination of the Ag⁺ ions dissociates the hydrogels into a solution phase.

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Article information

DOI: https://doi.org/10.1039/C3CC49140D
Article type: Communication
Submitted: 01 Dec 2013
Accepted: 13 Feb 2014
First published: 13 Feb 2014

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Chem. Commun., 2014,50, 4065-4068

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Reversible Ag⁺-crosslinked DNA hydrogels

W. Guo, X. Qi, R. Orbach, C. Lu, L. Freage, I. Mironi-Harpaz, D. Seliktar, H. Yang and I. Willner, Chem. Commun., 2014, 50, 4065 DOI: 10.1039/C3CC49140D

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Chemical Communications