Issue 30, 2014

Amino acid-linked platinum(ii) analogues have altered specificity for RNA compared to cisplatin

Abstract

Cisplatin can be modified with various ligands to alter the size and charge distribution of the complex. Several amino acid-linked platinum(II) complexes were synthesized, and a reactivity study with 16S ribosomal RNA was carried out. The amino acid-linked analogues show altered specificity compared to the parental compound cisplatin.

Graphical abstract: Amino acid-linked platinum(ii) analogues have altered specificity for RNA compared to cisplatin

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2013
Accepted
18 Dec 2013
First published
19 Dec 2013

Chem. Commun., 2014,50, 3918-3920

Author version available

Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin

K. Rijal, X. Bao and C. S. Chow, Chem. Commun., 2014, 50, 3918 DOI: 10.1039/C3CC49035A

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