Issue 12, 2014
From the journal:

Chemical Communications

Rhodium/phospholane–phosphite catalysts give unusually high regioselectivity in the enantioselective hydroformylation of vinyl arenes†

Gary M. Noonan,a   Christopher J. Cobley,*b   Thomas Mahoneyb  and  Matthew L. Clarke*a  

* Corresponding authors

a School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK
E-mail: mc28@st-andrews.ac.uk
Fax: +44 (0)1334 463808
Tel: +44 (0)1334 463850

b Chirotech Technology Ltd., Dr Reddys Laboratories (EU) Limited, 410 Cambridge Science Park, Milton road, Cambridge, UK
E-mail: ccobley@drreddys.com

Abstract

Using the phospholane–phosphite ligand, BOBPHOS, almost perfect regioselectivities and high enantioselectivities (up to 92% ee) are observed in Rh catalysed enantioselective hydroformylation of vinyl arenes. This can be achieved under solvent-free conditions.

Graphical abstract: Rhodium/phospholane–phosphite catalysts give unusually high regioselectivity in the enantioselective hydroformylation of vinyl arenes

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Article information

DOI
https://doi.org/10.1039/C3CC48823C
Article type
Communication
Submitted
19 Nov 2013
Accepted
13 Dec 2013
First published
16 Dec 2013

Chem. Commun., 2014,50, 1475-1477

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Rhodium/phospholane–phosphite catalysts give unusually high regioselectivity in the enantioselective hydroformylation of vinyl arenes

G. M. Noonan, C. J. Cobley, T. Mahoney and M. L. Clarke, Chem. Commun., 2014, 50, 1475 DOI: 10.1039/C3CC48823C

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