Issue 8, 2014

Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones

Abstract

A Rh2(OAc)4-catalyzed diazo decomposition reaction of diazo esters with 2-aminophenyl ketones is reported. A series of 3-hydroxy-2,2,3-trisubstituted indolines are produced in good yields with excellent diastereoselectivities via an intramolecular aldol-type trapping of ammonium ylides with ketone units.

Graphical abstract: Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones

Supplementary files

Article information

Article type
Communication
Submitted
21 Oct 2013
Accepted
15 Nov 2013
First published
18 Nov 2013

Chem. Commun., 2014,50, 951-953

Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones

C. Jing, D. Xing and W. Hu, Chem. Commun., 2014, 50, 951 DOI: 10.1039/C3CC48067D

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