Issue 40, 2014

Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

Abstract

We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.

Graphical abstract: Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

Supplementary files

Article information

Article type
Communication
Submitted
14 Oct 2013
Accepted
29 Oct 2013
First published
31 Oct 2013

Chem. Commun., 2014,50, 5248-5250

Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

D. Tan, V. Štrukil, C. Mottillo and T. Friščić, Chem. Commun., 2014, 50, 5248 DOI: 10.1039/C3CC47905F

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