Issue 2, 2014
From the journal:

Chemical Communications

Label-free and ultrasensitive fluorescence detection of cocaine based on a strategy that utilizes DNA-templated silver nanoclusters and the nicking endonuclease-assisted signal amplification method†

Kai Zhang,*a   Ke Wang,a   Xue Zhu,a   Jue Zhang,a   Lan Xu,a   Biao Huanga  and  Minhao Xie*a  

* Corresponding authors

a Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China
E-mail: zhangkai@jsinm.org, xieminhao@jsinm.org
Fax: +86-510-85520770
Tel: +86-510-85514482

Abstract

A general and reliable strategy for the detection of cocaine was proposed utilizing DNA-templated silver nanoclusters as signal indicators and the nicking endonuclease-assisted signal amplification method. This strategy can detect cocaine specifically with a detection limit as low as 2 nM by using a small volume of 5 μL.

Graphical abstract: Label-free and ultrasensitive fluorescence detection of cocaine based on a strategy that utilizes DNA-templated silver nanoclusters and the nicking endonuclease-assisted signal amplification method

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Article information

DOI
https://doi.org/10.1039/C3CC47418F
Article type
Communication
Submitted
28 Sep 2013
Accepted
23 Oct 2013
First published
24 Oct 2013

Chem. Commun., 2014,50, 180-182

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Label-free and ultrasensitive fluorescence detection of cocaine based on a strategy that utilizes DNA-templated silver nanoclusters and the nicking endonuclease-assisted signal amplification method

K. Zhang, K. Wang, X. Zhu, J. Zhang, L. Xu, B. Huang and M. Xie, Chem. Commun., 2014, 50, 180 DOI: 10.1039/C3CC47418F

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