Issue 20, 2014
From the journal:

Chemical Communications

Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c†

Daiana A. Capdevila,a   Damián Álvarez-Paggi,a   María A. Castro,a   Verónica Tórtora,b   Verónica Demicheli,b   Darío A. Estrín,a   Rafael Radi*b  and  Daniel H. Murgida*a  

* Corresponding authors

a Departamento de Química Inorgánica, Analítica y Química Física and INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires-CONICET, Argentina
E-mail: dhmurgida@qi.fcen.uba.ar

b Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
E-mail: rradi@fmed.edu.uy

Abstract

Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.

Graphical abstract: Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c

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Article information

DOI
https://doi.org/10.1039/C3CC47207H
Article type
Communication
Submitted
20 Sep 2013
Accepted
27 Nov 2013
First published
28 Nov 2013

Chem. Commun., 2014,50, 2592-2594

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Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c

D. A. Capdevila, D. Álvarez-Paggi, M. A. Castro, V. Tórtora, V. Demicheli, D. A. Estrín, R. Radi and D. H. Murgida, Chem. Commun., 2014, 50, 2592 DOI: 10.1039/C3CC47207H

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