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Issue 9, 2014
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Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release

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Abstract

The reaction of bis-sulfone conjugation reagents with disulfide bonds allows the site-specific modification of various peptides and proteins. Herein, we present the intracellular disintegration of bis-sulfide containing somatostatin bioconjugates under controlled, tumor-relevant glutathione levels. GSH responsive release is demonstrated, which offers high potential for designing tumor responsive therapeutics.

Graphical abstract: Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release

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Publication details

The article was received on 12 Sep 2013, accepted on 08 Nov 2013 and first published on 11 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47003B
Citation: Chem. Commun., 2014,50, 1116-1118
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    Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release

    T. Wang, D. Y. W. Ng, Y. Wu, J. Thomas, T. TamTran and T. Weil, Chem. Commun., 2014, 50, 1116
    DOI: 10.1039/C3CC47003B

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