Jump to main content
Jump to site search

Issue 3, 2014
Previous Article Next Article

Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

Author affiliations

Abstract

Efficient palladium-catalysed cascade cyclisation to form spiroindoles is developed. Treatment of indoles bearing a propargyl chloride side chain at the 3-position with various external nucleophiles in the presence of a catalytic amount of Pd2(dba)3·CHCl3/dppb and Cs2CO3 in THF gives fused tetracyclic spiroindoles in moderate to good yields.

Graphical abstract: Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Aug 2013, accepted on 27 Oct 2013 and first published on 28 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46511J
Citation: Chem. Commun., 2014,50, 298-300
  •   Request permissions

    Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

    A. Iwata, S. Inuki, S. Oishi, N. Fujii and H. Ohno, Chem. Commun., 2014, 50, 298
    DOI: 10.1039/C3CC46511J

Search articles by author

Spotlight

Advertisements