Jump to main content
Jump to site search

Issue 5, 2014
Previous Article Next Article

Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity

Author affiliations

Abstract

A novel 2′,4′-BNA/LNA analog bridged by guanidine, termed as guanidine bridged nucleic acid (GuNA), was synthesized and incorporated into oligonucleotides. Thermal stabilities and nuclease resistance of GuNA-modified oligonucleotides were investigated and compared with those of 2′,4′-BNA/LNA and natural DNA oligonucleotides. GuNA exhibited interestingly high binding affinity towards complementary ssDNA than 2′,4′-BNA/LNA.

Graphical abstract: Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Aug 2013, accepted on 05 Nov 2013 and first published on 06 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC46017G
Citation: Chem. Commun., 2014,50, 575-577
  •   Request permissions

    Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity

    A. R. Shrestha, Y. Kotobuki, Y. Hari and S. Obika, Chem. Commun., 2014, 50, 575
    DOI: 10.1039/C3CC46017G

Search articles by author

Spotlight

Advertisements