Issue 5, 2014

Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide

Abstract

3-((Trifluoromethyl)thio)indoles can be synthesized by a palladium(II)-catalyzed reaction of 2-alkynylaniline with trifluoromethanesulfanylamide in the presence of bismuth(III) chloride. The presence of bismuth(III) chloride is crucial for the success of this transformation, which activates the trifluoromethanesulfanylamide during the reaction.

Graphical abstract: Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide

Supplementary files

Article information

Article type
Communication
Submitted
05 Aug 2013
Accepted
18 Oct 2013
First published
21 Oct 2013

Chem. Commun., 2014,50, 578-580

Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide

J. Sheng, S. Li and J. Wu, Chem. Commun., 2014, 50, 578 DOI: 10.1039/C3CC45958F

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