SCHEDULED MAINTENANCE
The Negishi coupling reaction between arylzinc halide reagents and 11CH3I has been used to synthesise 11C-methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [11C]MPEP has been radiolabelled using this technique.
![Graphical abstract: Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C3CC47203E&imageInfo.ImageIdentifier.Year=2013)
S. Kealey, J. Passchier and M. Huiban, Chem. Commun., 2013, 49, 11326 DOI: 10.1039/C3CC47203E
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