Issue 95, 2013
From the journal:

Chemical Communications

Stabilized Wittig olefination for bioconjugation†

Kenneth M. Lum,a   Vanessa J. Xavier,a   Michelle J.-H. Ong,a   Charles W. Johannesa  and  Kok-Ping Chan*a  

* Corresponding authors

a Division of Organic Chemistry, Institute of Chemical and Engineering Sciences, Agency for Science Technology and Research Singapore, 11 Biopolis Way, Helios Block #03-08, Singapore
E-mail: chan_kok_ping@ices.a-star.edu.sg
Fax: +65 6874 5870
Tel: +65 6799 8599

Abstract

Stabilized Wittig olefination holds great potential as a bioconjugation reaction. We demonstrate that the reaction of stabilized phosphorus ylides (or phosphonium salts) with aryl aldehydes is sufficiently robust to be used for live cell affinity isolation and fluorescence tagging of a protein, FKBP12.

Graphical abstract: Stabilized Wittig olefination for bioconjugation

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Article information

DOI
https://doi.org/10.1039/C3CC45961F
Article type
Communication
Submitted
05 Aug 2013
Accepted
11 Oct 2013
First published
14 Oct 2013

Chem. Commun., 2013,49, 11188-11190

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Stabilized Wittig olefination for bioconjugation

K. M. Lum, V. J. Xavier, M. J.-H. Ong, C. W. Johannes and K. Chan, Chem. Commun., 2013, 49, 11188 DOI: 10.1039/C3CC45961F

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