Issue 83, 2013
From the journal:

Chemical Communications

Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule microarray†

Jiaqi Fu,a   Zhenkun Na,a   Mahesh Uttamchandani*ab  and  Shao Q. Yao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyaosq@nus.edu.sg
Fax: +65 67791691
Tel: +65 65162925

b Department of Biological Sciences, National University of Singapore, and Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, Singapore 117510
E-mail: mahesh@dso.org.sg
Fax: +65 64857033
Tel: +65 64857206

Abstract

A 396-member peptide-hybrid small molecule microarray was fabricated to profile small molecule ligands across 15 SH2 proteins, revealing hits against Lck and Grb2.

Graphical abstract: Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule microarray

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC45413D
Article type
Communication
Submitted
17 Jul 2013
Accepted
21 Aug 2013
First published
21 Aug 2013

Chem. Commun., 2013,49, 9660-9662

Permissions

Request permissions

Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule microarray

J. Fu, Z. Na, M. Uttamchandani and S. Q. Yao, Chem. Commun., 2013, 49, 9660 DOI: 10.1039/C3CC45413D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements