Issue 84, 2013
From the journal:

Chemical Communications

A new strategy for designing a graphene oxide-based DNA hairpin probe: fluorescence upon switching the orientation of the sticky end†

Jin Huang,ab   Xiaohai Yang,ab   Xiaoxiao He,ac   Kemin Wang,*abc   Yong Heab  and  Ke Quanab  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China
E-mail: kmwang@hnu.edu.cn

b College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China

c College of Biology, Hunan University, Changsha 410082, P. R. China

Abstract

Here we report a new strategy for designing a graphene oxide (GO)-quenched dye-labeled DNA hairpin probe by utilizing the sticky end adsorbed onto the GO surface. Only introduction of target DNA can alter the orientation of the sticky end, causing the dye to move apart from the GO surface, resulting in fluorescence restoration.

Graphical abstract: A new strategy for designing a graphene oxide-based DNA hairpin probe: fluorescence upon switching the orientation of the sticky end

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Article information

DOI
https://doi.org/10.1039/C3CC45307C
Article type
Communication
Submitted
14 Jul 2013
Accepted
25 Aug 2013
First published
28 Aug 2013

Chem. Commun., 2013,49, 9827-9829

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A new strategy for designing a graphene oxide-based DNA hairpin probe: fluorescence upon switching the orientation of the sticky end

J. Huang, X. Yang, X. He, K. Wang, Y. He and K. Quan, Chem. Commun., 2013, 49, 9827 DOI: 10.1039/C3CC45307C

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