Issue 83, 2013
From the journal:

Chemical Communications

An efficient synthesis of polysubstituted pyrroles via copper-catalyzed coupling of oxime acetates with dialkyl acetylenedicarboxylates under aerobic conditions†

Xiaodong Tang,a   Liangbin Huang,a   Chaorong Qi,a   Wanqing Wua  and  Huanfeng Jiang*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China
E-mail: jianghf@scut.edu.cn
Fax: +86 20-87112906
Tel: +86 20-87112906

Abstract

A Cu-catalyzed [3+2]-type condensation reaction of oxime acetates and dialkyl acetylenedicarboxylates that provides highly substituted pyrroles under aerobic conditions is described. The newly formed pyrroles are easily employed for further transformations to prepare pyrrolo[2,1-a]isoquinoline skeletons.

Graphical abstract: An efficient synthesis of polysubstituted pyrroles via copper-catalyzed coupling of oxime acetates with dialkyl acetylenedicarboxylates under aerobic conditions

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Article information

DOI
https://doi.org/10.1039/C3CC44896G
Article type
Communication
Submitted
30 Jun 2013
Accepted
20 Aug 2013
First published
20 Aug 2013

Chem. Commun., 2013,49, 9597-9599

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An efficient synthesis of polysubstituted pyrroles via copper-catalyzed coupling of oxime acetates with dialkyl acetylenedicarboxylates under aerobic conditions

X. Tang, L. Huang, C. Qi, W. Wu and H. Jiang, Chem. Commun., 2013, 49, 9597 DOI: 10.1039/C3CC44896G

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