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Issue 75, 2013
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Light-inducible activation of target mRNA translation in mammalian cells

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Abstract

A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.

Graphical abstract: Light-inducible activation of target mRNA translation in mammalian cells

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Publication details

The article was received on 28 Jun 2013, accepted on 17 Jul 2013 and first published on 08 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC44866E
Citation: Chem. Commun., 2013,49, 8338-8340
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    Light-inducible activation of target mRNA translation in mammalian cells

    J. Cao, M. Arha, C. Sudrik, L. J. Bugaj, D. V. Schaffer and R. S. Kane, Chem. Commun., 2013, 49, 8338
    DOI: 10.1039/C3CC44866E

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