Issue 74, 2013
From the journal:

Chemical Communications

Palladium-catalyzed oxidative direct C–H/C–H cross coupling of anilides with β-keto esters†

Wai-Wing Chan,a   Zhongyuan Zhoua  and  Wing-Yiu Yu*a  

* Corresponding authors

a State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
E-mail: wing-yiu.yu@polyu.edu.hk

Abstract

A Pd(II)-catalyzed oxidative direct C(sp2)–H/C(sp3)–H cross coupling of anilides with α-dicarbonyl compounds with Mn(OAc)3·2H2O as the oxidant is reported and this protocol provides facile access to α-aryl malonates and β-keto esters in good yields and regioselectivity.

Graphical abstract: Palladium-catalyzed oxidative direct C–H/C–H cross coupling of anilides with β-keto esters

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Article information

DOI
https://doi.org/10.1039/C3CC44769C
Article type
Communication
Submitted
25 Jun 2013
Accepted
15 Jul 2013
First published
16 Jul 2013

Chem. Commun., 2013,49, 8214-8216

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Palladium-catalyzed oxidative direct C–H/C–H cross coupling of anilides with β-keto esters

W. Chan, Z. Zhou and W. Yu, Chem. Commun., 2013, 49, 8214 DOI: 10.1039/C3CC44769C

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