Issue 69, 2013
From the journal:

Chemical Communications

Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition†

Boram Kim,‡ab   Sung-ju Choi,‡ab   So-hee Han,ab   Kang-Yell Choiac  and  Yong-beom Lim*ab  

* Corresponding authors

a Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Korea
E-mail: yblim@yonsei.ac.kr
Fax: +82 2 3125375
Tel: +82 2 21235836

b Department of Materials Science & Engineering, Yonsei University, Seoul 120-749, Korea

c Department of Biotechnology, Yonsei University, Seoul 120-749, Korea

Abstract

A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein–protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.

Graphical abstract: Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

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Article information

DOI
https://doi.org/10.1039/C3CC44644A
Article type
Communication
Submitted
20 Jun 2013
Accepted
27 Jun 2013
First published
28 Jun 2013

Chem. Commun., 2013,49, 7617-7619

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Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

B. Kim, S. Choi, S. Han, K. Choi and Y. Lim, Chem. Commun., 2013, 49, 7617 DOI: 10.1039/C3CC44644A

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