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Issue 90, 2013
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“One pot” regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions

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Abstract

A convenient “one-pot” weak base-promoted synthesis of polysubstituted pyrroles has been developed from benzylamines and ynones. This transformation involves the Michael addition reaction and intramolecular condensation, which features high regioselectivity, high efficiency, environmental friendliness and metal free. A series of polysubstituted pyrroles were provided in up to 91% yield for 27 examples.

Graphical abstract: “One pot” regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions

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Publication details

The article was received on 22 May 2013, accepted on 14 Sep 2013 and first published on 17 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC43844A
Citation: Chem. Commun., 2013,49, 10641-10643
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    “One pot” regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions

    J. Shen, G. Cheng and X. Cui, Chem. Commun., 2013, 49, 10641
    DOI: 10.1039/C3CC43844A

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