Issue 74, 2013
From the journal:

Chemical Communications

The force of transporting a single amino acid into the living cell measured using atomic force microscopy†

Xin Shang,‡a   Yuping Shan,‡b   Yangang Pan,‡a   Mingjun Cai,a   Junguang Jianga  and  Hongda Wang*a  

* Corresponding authors

a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China
E-mail: hdwang@ciac.jl.cn

b Department of Physics, Florida International University, Miami, FL 33199, USA

Abstract

We used single molecule force spectroscopy (SMFS) to investigate the interacting force between single cysteine and amino acid transporters in eukaryotic cell membranes. We measured the transporting force of cysteine and found that its conformation on the AFM tip is important for discriminating the substrate in the transporting pathway.

Graphical abstract: The force of transporting a single amino acid into the living cell measured using atomic force microscopy

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Article information

DOI
https://doi.org/10.1039/C3CC43779E
Article type
Communication
Submitted
20 May 2013
Accepted
17 Jul 2013
First published
17 Jul 2013

Chem. Commun., 2013,49, 8163-8165

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The force of transporting a single amino acid into the living cell measured using atomic force microscopy

X. Shang, Y. Shan, Y. Pan, M. Cai, J. Jiang and H. Wang, Chem. Commun., 2013, 49, 8163 DOI: 10.1039/C3CC43779E

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