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Issue 82, 2013
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Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

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Abstract

Quaternized polymers mimicking the antimicrobial peptides were created by tuning the side-chain amphiphilicity using a first-time approach of post-functionalization. They displayed excellent efficacy against pathogenic bacteria even in human plasma and membrane disruptive mode of action. The optimized polymers and degraded products were non-hemolytic.

Graphical abstract: Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

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Publication details

The article was received on 18 May 2013, accepted on 28 Jun 2013 and first published on 28 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC43751E
Citation: Chem. Commun., 2013,49, 9389-9391
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    Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

    D. S. S. M. Uppu, P. Akkapeddi, G. B. Manjunath, V. Yarlagadda, J. Hoque and J. Haldar, Chem. Commun., 2013, 49, 9389
    DOI: 10.1039/C3CC43751E

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