A supramolecular DNA self-assembly based on β-cyclodextrin–adamantane complexation as a bioorthogonal sticky end motif

Abstract

We propose linear end-to-end assemblies of short DNA duplexes based on β-cyclodextrin–adamantane complexation. The assembled duplexes exhibited increased T_m values compared with those of the corresponding natural hybrids. Competition experiments with external guest molecules showed a substantial decrease in T_m of the terminal modified duplexes, suggesting the viability of inter-duplex complexation.