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Issue 87, 2013
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Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

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Abstract

The complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.

Graphical abstract: Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

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The article was received on 23 Apr 2013, accepted on 25 Jun 2013 and first published on 26 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC43000F
Citation: Chem. Commun., 2013,49, 10224-10226
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    Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

    W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. Wang, Z. Du, X. Hao, Y. Yu, S. Lü, L. Ji, X. Li, L. Yang and F. Wang, Chem. Commun., 2013, 49, 10224
    DOI: 10.1039/C3CC43000F

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