AlCl3-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

Ali Nakhi; Sivakumar Archana; Guru Pavan Kumar Seerapu; Keerthana Sarma Chennubhotla; Kummari Lalith Kumar; Pushkar Kulkarni; Devyani Haldar; Manojit Pal

doi:10.1039/C3CC42840K

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AlCl₃-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest†

Ali Nakhi,^a Sivakumar Archana,^ab Guru Pavan Kumar Seerapu,^a Keerthana Sarma Chennubhotla,^ac Kummari Lalith Kumar,^a Pushkar Kulkarni,^ac Devyani Haldar^a and Manojit Pal*^a

Author affiliations

* Corresponding authors

^a Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

^b Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India

^c Zephase Therapeutics (an incubated company at the DRILS), University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India

Abstract

An unprecedented AlCl₃-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

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Article information

DOI: https://doi.org/10.1039/C3CC42840K
Article type: Communication
Submitted: 17 Apr 2013
Accepted: 21 May 2013
First published: 22 May 2013

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Chem. Commun., 2013,49, 6268-6270

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AlCl₃-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

A. Nakhi, S. Archana, G. P. K. Seerapu, K. S. Chennubhotla, K. L. Kumar, P. Kulkarni, D. Haldar and M. Pal, Chem. Commun., 2013, 49, 6268 DOI: 10.1039/C3CC42840K

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