The first general route for efficient synthesis of 18O labelled alcohols using the HOF·CH3CN complex

Julia Gatenyo; Inna Vints; Shlomo Rozen

doi:10.1039/C3CC42337A

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The first general route for efficient synthesis of ¹⁸O labelled alcohols using the HOF·CH₃CN complex†

Julia Gatenyo,^a Inna Vints^a and Shlomo Rozen*^a

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* Corresponding authors

^a School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel
E-mail: rozens@post.tau.ac.il
Fax: +972 3640 9293
Tel: +972 3640 8378

Abstract

A mild and very efficient method for converting boronic acids to alcohols has been developed using the acetonitrile complex of hypofluorous acid HOF·CH₃CN. Employing ¹⁸O-labeled water results in alcohols containing a heavy oxygen isotope. The reactions were performed at room temperature, within a few minutes and in excellent yields.

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Article information

DOI: https://doi.org/10.1039/C3CC42337A
Article type: Communication
Submitted: 31 Mar 2013
Accepted: 13 May 2013
First published: 14 May 2013

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Chem. Commun., 2013,49, 7379-7381

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The first general route for efficient synthesis of ¹⁸O labelled alcohols using the HOF·CH₃CN complex

J. Gatenyo, I. Vints and S. Rozen, Chem. Commun., 2013, 49, 7379 DOI: 10.1039/C3CC42337A

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Chemical Communications