Issue 59, 2013
From the journal:

Chemical Communications

Facile synthesis of benzofuransvia copper-catalyzed aerobic oxidative cyclization of phenols and alkynes†

Wei Zeng,a   Wanqing Wu,a   Huanfeng Jiang,*a   Liangbin Huang,a   Yadong Sun,a   Zhengwang Chena  and  Xianwei Lia  

* Corresponding authors

a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China
E-mail: jianghf@scut.edu.cn
Fax: +8620-87112906
Tel: +8620-87112906

Abstract

Regioselective synthesis of polysubstituted benzofurans using a copper catalyst and molecular oxygen from phenols and alkynes in a one-pot procedure has been reported. The transformation consists of a sequential nucleophilic addition of phenols to alkynes and oxidative cyclization. A wide variety of phenols and alkynes can be used in the same manner.

Graphical abstract: Facile synthesis of benzofurans via copper-catalyzed aerobic oxidative cyclization of phenols and alkynes

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Article information

DOI
https://doi.org/10.1039/C3CC42326C
Article type
Communication
Submitted
30 Mar 2013
Accepted
03 Jun 2013
First published
04 Jun 2013

Chem. Commun., 2013,49, 6611-6613

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Facile synthesis of benzofurans via copper-catalyzed aerobic oxidative cyclization of phenols and alkynes

W. Zeng, W. Wu, H. Jiang, L. Huang, Y. Sun, Z. Chen and X. Li, Chem. Commun., 2013, 49, 6611 DOI: 10.1039/C3CC42326C

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