Issue 85, 2013
From the journal:

Chemical Communications

Synthesis and antitumor activity of a series of osmium(vi) nitrido complexes bearing quinolinolato ligands†

Quan Tang,‡abc   Wen-Xiu Ni,‡b   Chi-Fai Leung,bd   Wai-Lun Man,b   Kenneth King-Kwan Lau,b   Yimin Liang,b   Yun-Wah Lam,b   Wai-Yeung Wong,e   Shie-Ming Peng,f   Gui-Jian Liu*ac  and  Tai-Chu Lau*ab  

* Corresponding authors

a Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-CityU, Hefei, Anhui 230601, China

b Department of Biology and Chemistry, City University of Hong Kong, and Institute of Molecular Functional Materials, Tat Chee Avenue, Kowloon Tong, Hong Kong, China
E-mail: bhtclau@cityu.edu.hk
Fax: +852 34420522

c CAS Key Laboratory of Crust-Mantle Materials and the Environments, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: lgj@ustc.edu.cn

d Department of Science and Environmental Studies, The Hong Kong Institute of Education, 10 Lo Ping Road, Tai Po, New Territories, Hong Kong, China

e Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China

f Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, Republic of China

Abstract

A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that OsVI[triple bond, length as m-dash]N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.

Graphical abstract: Synthesis and antitumor activity of a series of osmium(vi) nitrido complexes bearing quinolinolato ligands

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Article information

DOI
https://doi.org/10.1039/C3CC42250J
Article type
Communication
Submitted
28 Mar 2013
Accepted
27 Aug 2013
First published
28 Aug 2013

Chem. Commun., 2013,49, 9980-9982

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Synthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands

Q. Tang, W. Ni, C. Leung, W. Man, K. K. Lau, Y. Liang, Y. Lam, W. Wong, S. Peng, G. Liu and T. Lau, Chem. Commun., 2013, 49, 9980 DOI: 10.1039/C3CC42250J

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