Issue 45, 2013

A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification

Abstract

A hairpin DNA probe mediated cascade signal amplification method was developed for visual and rapid DNA analysis with a detection limit of 100 aM. The implementation of tag/anti-tag DNA and gold nanoparticle reporters permits a universal platform for multiplex genotyping without instrumentation.

Graphical abstract: A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification

Supplementary files

Article information

Article type
Communication
Submitted
15 Mar 2013
Accepted
09 Apr 2013
First published
10 Apr 2013

Chem. Commun., 2013,49, 5165-5167

A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification

J. Liu, L. Chen, P. Lie, B. Dun and L. Zeng, Chem. Commun., 2013, 49, 5165 DOI: 10.1039/C3CC41941J

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