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Issue 34, 2013
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Complete shift of ferritin oligomerization toward nanocage assembly via engineered proteinprotein interactions

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Abstract

Computational redesign of a dimorphic protein nano-cage at the C3-symmetrical interfaces forces it to assemble into the monomorphic cage. These monodisperse assemblies are at least 20 °C more stable than the parent. This approach adds to the toolkit of bottom-up molecular design with applications in protein engineering and hybrid nano-materials.

Graphical abstract: Complete shift of ferritin oligomerization toward nanocage assembly via engineered protein–protein interactions

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Publication details

The article was received on 01 Feb 2013, accepted on 11 Mar 2013 and first published on 12 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40886H
Citation: Chem. Commun., 2013,49, 3528-3530
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    Complete shift of ferritin oligomerization toward nanocage assembly via engineered proteinprotein interactions

    M. S. Ardejani, X. L. Chok, C. J. Foo and B. P. Orner, Chem. Commun., 2013, 49, 3528
    DOI: 10.1039/C3CC40886H

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