Issue 28, 2013

Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

Abstract

A general method for the facile and versatile decoration of peptides is proposed exploiting furan based cycloaddition and electrophilic aromatic substitution reactions. Given the commercial availability of furylalanine derivatives for peptide synthesis, the current work significantly enlarges the toolbox of available methodologies for site specific labeling and conjugation of peptide probes.

Graphical abstract: Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

Supplementary files

Article information

Article type
Communication
Submitted
23 Jan 2013
Accepted
21 Feb 2013
First published
22 Feb 2013

Chem. Commun., 2013,49, 2927-2929

Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

K. Hoogewijs, D. Buyst, J. M. Winne, J. C. Martins and A. Madder, Chem. Commun., 2013, 49, 2927 DOI: 10.1039/C3CC40588E

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