Issue 35, 2013

Unexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: synthesis of secondary amines

Abstract

Selective ruthenium-catalyzed reductive coupling of primary amides under hydrosilylation conditions is achieved using an one pot procedure. Using 3 equiv. of phenylsilane and [RuCl2(mesitylene)]2 (1–2 mol%) as the catalyst at 100 °C under neat conditions, secondary symmetric amines were obtained in good yields and with high chemoselectivities.

Graphical abstract: Unexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: synthesis of secondary amines

Supplementary files

Article information

Article type
Communication
Submitted
21 Dec 2012
Accepted
01 Mar 2013
First published
01 Mar 2013

Chem. Commun., 2013,49, 3691-3693

Unexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: synthesis of secondary amines

B. Li, J. Sortais and C. Darcel, Chem. Commun., 2013, 49, 3691 DOI: 10.1039/C3CC39149C

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