Issue 17, 2013
From the journal:

Chemical Communications

SnO2–ZnSn(OH)6: a novel binary affinity probe for global phosphopeptide detection†

Li-Ping Li,a   Tao Zheng,b   Lin-Nan Xu,a   Ze Li,a   Ling-Dong Sun,b   Zong-Xiu Nie,c   Yu Bai*a  and  Hu-Wei Liu*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
E-mail: yu.bai@pku.edu.cn, hwliu@pku.edu.cn
Fax: +86 10 6275 1708
Tel: +86 10 6275 8198

b State Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU-HKU Joint Lab on Rare Earth Materials and Bioinorganic Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China

c Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, China

Abstract

ZnSn(OH)6 and binary-component SnO2–ZnSn(OH)6 were introduced as affinity probes for phosphopeptide enrichment for the first time. Two strategies, either ZnSn(OH)6 and SnO2 serial enrichment or binary-component SnO2–ZnSn(OH)6 enrichment in a single run, were proposed to enhance multi-phosphopeptide enrichment and to significantly improve global phosphopeptide detection.

Graphical abstract: SnO2–ZnSn(OH)6: a novel binary affinity probe for global phosphopeptide detection

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Article information

DOI
https://doi.org/10.1039/C3CC38909J
Article type
Communication
Submitted
13 Dec 2012
Accepted
14 Jan 2013
First published
15 Jan 2013

Chem. Commun., 2013,49, 1762-1764

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SnO2–ZnSn(OH)6: a novel binary affinity probe for global phosphopeptide detection

L. Li, T. Zheng, L. Xu, Z. Li, L. Sun, Z. Nie, Y. Bai and H. Liu, Chem. Commun., 2013, 49, 1762 DOI: 10.1039/C3CC38909J

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