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Issue 21, 2013
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Synthesis of selective inhibitors of sphingosine kinase 1

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Abstract

Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC50 = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.

Graphical abstract: Synthesis of selective inhibitors of sphingosine kinase 1

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Publication details

The article was received on 09 Jan 2013, accepted on 24 Jan 2013 and first published on 28 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC00181D
Citation: Chem. Commun., 2013,49, 2136-2138
  • Open access: Creative Commons BY license
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    Synthesis of selective inhibitors of sphingosine kinase 1

    D. J. Baek, N. MacRitchie, N. J. Pyne, S. Pyne and R. Bittman, Chem. Commun., 2013, 49, 2136
    DOI: 10.1039/C3CC00181D

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