Issue 24, 2013

Layer by layer assembly of biotinylated protein networks for signal amplification

Abstract

Described herein is a unique and inexpensive method that outperforms commercial methods that amplify the streptavidin–biotin recognition event. Amplification induced by streptavidin and biotinylated protein causes the formation of a large detectable polymer. This approach enjoys a 100-fold decrease in detection limit in comparison with the commercial methods.

Graphical abstract: Layer by layer assembly of biotinylated protein networks for signal amplification

Supplementary files

Article information

Article type
Communication
Submitted
15 Nov 2012
Accepted
07 Jan 2013
First published
07 Jan 2013

Chem. Commun., 2013,49, 2397-2399

Layer by layer assembly of biotinylated protein networks for signal amplification

Y. W. Chu, B. Y. Wang, H. Lin, T. Lin, Y. Hung, D. A. Engebretson, W. Lee and J. R. Carey, Chem. Commun., 2013, 49, 2397 DOI: 10.1039/C2CC38233D

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