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Issue 7, 2013
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Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C–H bond acylation of acetanilides

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Abstract

A palladium-catalyzed cascade cross-coupling of acetanilide and toluene for the synthesis of ortho-acylacetanilide is described. Toluene derivatives can act as effective acyl precursors (upon sp3-C–H bond oxidation by a Pd/TBHP system) in the oxidative coupling between two C–H bonds. This dehydrogenative Pd-catalyzed ortho-acylation proceeds under mild reaction conditions.

Graphical abstract: Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C–H bond acylation of acetanilides

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Publication details

The article was received on 08 Oct 2012, accepted on 03 Dec 2012 and first published on 03 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC37352A
Citation: Chem. Commun., 2013,49, 689-691
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    Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C–H bond acylation of acetanilides

    Y. Wu, P. Y. Choy, F. Mao and F. Y. Kwong, Chem. Commun., 2013, 49, 689
    DOI: 10.1039/C2CC37352A

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