Synthesis of phenanthridinones via palladium-catalyzed C(sp2)–H aminocarbonylation of unprotected o-arylanilines

Dongdong Liang; Ziwei Hu; Jiangling Peng; Jinbo Huang; Qiang Zhu

doi:10.1039/C2CC36817J

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Synthesis of phenanthridinones viapalladium-catalyzed C(sp²)–H aminocarbonylation of unprotected o-arylanilines†

Dongdong Liang,^a Ziwei Hu,^a Jiangling Peng,^a Jinbo Huang^a and Qiang Zhu*^a

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* Corresponding authors

^a State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China
E-mail: zhu_qiang@gibh.ac.cn
Fax: +86 20-3201-5299
Tel: +86 20-3201-5287

Abstract

An efficient synthesis of free (NH)-phenanthridinones through Pd-catalyzed C(sp²)–H aminocarbonylation of unprotected o-arylanilines under an atmospheric pressure of CO has been developed. Some ortho heteroarene substituted anilines as well as N-alkyl protected o-arylanilines are also suitable substrates for this C–H aminocarbonylation reaction.

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Article information

DOI: https://doi.org/10.1039/C2CC36817J
Article type: Communication
Submitted: 19 Sep 2012
Accepted: 03 Nov 2012
First published: 05 Nov 2012

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Chem. Commun., 2013,49, 173-175

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Synthesis of phenanthridinones via palladium-catalyzed C(sp²)–H aminocarbonylation of unprotected o-arylanilines

D. Liang, Z. Hu, J. Peng, J. Huang and Q. Zhu, Chem. Commun., 2013, 49, 173 DOI: 10.1039/C2CC36817J

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