Issue 92, 2012

Transition metal-free direct C–H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes

Abstract

A convenient transition metal-free procedure for the direct thiolation of 1,3,4-oxadiazole C–H bonds using diaryl disulfides has been developed. Other substrates including indole, benzothiazole, N-phenylbenzimidazole, and caffeine were also thiolated in this manner, providing the corresponding products in good to excellent yields.

Graphical abstract: Transition metal-free direct C–H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes

Supplementary files

Article information

Article type
Communication
Submitted
14 Sep 2012
Accepted
04 Oct 2012
First published
05 Oct 2012

Chem. Commun., 2012,48, 11307-11309

Transition metal-free direct C–H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes

L. Zou, J. Reball, J. Mottweiler and C. Bolm, Chem. Commun., 2012, 48, 11307 DOI: 10.1039/C2CC36711D

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