Issue 89, 2012
From the journal:

Chemical Communications

Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides†

Qi Xing,ab   Lijun Shi,a   Rui Lang,a   Chungu Xiaa  and  Fuwei Li*ac  

* Corresponding authors

a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China
E-mail: fuweili@licp.cas.cn
Fax: +86-931-4968129

b Graduate University of Chinese Academy of Sciences, Beijing, China

c Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China

Abstract

A novel and efficient double-carbonylation of indoles with primary or secondary amines to yield indole-3-α-ketoamides has been developed and bioactive molecules could be one-pot synthesized using the current methodology, which could also be selectively switched to mono-carbonylation to afford indole-3-amides only by a slight modification of reaction conditions.

Graphical abstract: Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC36341K
Article type
Communication
Submitted
31 Aug 2012
Accepted
23 Sep 2012
First published
25 Sep 2012

Chem. Commun., 2012,48, 11023-11025

Permissions

Request permissions

Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

Q. Xing, L. Shi, R. Lang, C. Xia and F. Li, Chem. Commun., 2012, 48, 11023 DOI: 10.1039/C2CC36341K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements