Issue 91, 2012
From the journal:

Chemical Communications

Copper-catalyzed ortho-acylation of phenols with aryl aldehydes and its application in one-step preparation of xanthones†

Jun Hu,a   Enoch A. Adogla,a   Yong Ju,b   Daping Fanc  and  Qian Wang*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of South Carolina, Columbia, USA
E-mail: WANG263@maibox.sc.edu

b Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

c School of Medicine, University of South Carolina, Columbia, USA

Abstract

In the presence of triphenylphosphine, copper(II) chloride can catalyze an intermolecular ortho-acylation reaction of phenols with aryl aldehydes. The reaction proceeds smoothly with a wide range of starting materials, and furthermore, it can be used to synthesize xanthone derivatives in a single step in high yields.

Graphical abstract: Copper-catalyzed ortho-acylation of phenols with aryl aldehydes and its application in one-step preparation of xanthones

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Article information

DOI
https://doi.org/10.1039/C2CC36176K
Article type
Communication
Submitted
24 Aug 2012
Accepted
26 Sep 2012
First published
03 Oct 2012

Chem. Commun., 2012,48, 11256-11258

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Copper-catalyzed ortho-acylation of phenols with aryl aldehydes and its application in one-step preparation of xanthones

J. Hu, E. A. Adogla, Y. Ju, D. Fan and Q. Wang, Chem. Commun., 2012, 48, 11256 DOI: 10.1039/C2CC36176K

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