A fluorescent probe capable of detecting H2S at submicromolar concentrations in cells

Weimin Xuan; Rong Pan; Yanting Cao; Kejian Liu; Wei Wang

doi:10.1039/C2CC35602C

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A fluorescent probe capable of detecting H₂S at submicromolar concentrations in cells†

Weimin Xuan,^a Rong Pan,^b Yanting Cao,^a Kejian Liu^b and Wei Wang*^a

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* Corresponding authors

^a Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA
E-mail: wwang@unm.edu
Fax: +1 505-277-2609

^b Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA

Abstract

A new internal charge transfer (ICT) fluorescent probe for highly selective and sensitive monitoring of H₂S has been developed. The design takes advantage of the facile reduction of non-fluorescent hydroxyamine naphthalimide by H₂S to highly fluorescent amine naphthalimide. It has been demonstrated that the probe is able to detect H₂S at submicromolar concentrations in cells.

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Supplementary files

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Article information

DOI: https://doi.org/10.1039/C2CC35602C
Article type: Communication
Submitted: 02 Aug 2012
Accepted: 09 Sep 2012
First published: 11 Sep 2012

Download Citation

Chem. Commun., 2012,48, 10669-10671

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A fluorescent probe capable of detecting H₂S at submicromolar concentrations in cells

W. Xuan, R. Pan, Y. Cao, K. Liu and W. Wang, Chem. Commun., 2012, 48, 10669 DOI: 10.1039/C2CC35602C

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Chemical Communications