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Issue 83, 2012
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Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

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Abstract

Here, we report 5-hydroxy-1,2,3,4,4a,9a-hexahydro-1,4-ethano-9,10-anthraquinone (13), a small molecule generating reactive oxygen species (ROS) in pH 7.4 buffer under ambient aerobic conditions that has selective and potent Mycobacterium tuberculosis growth inhibitory activity.

Graphical abstract: Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

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Publication details

The article was received on 24 Jul 2012, accepted on 20 Aug 2012 and first published on 21 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35343A
Citation: Chem. Commun., 2012,48, 10325-10327
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    Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

    A. T. Dharmaraja, M. Alvala, D. Sriram, P. Yogeeswari and H. Chakrapani, Chem. Commun., 2012, 48, 10325
    DOI: 10.1039/C2CC35343A

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