Issue 84, 2012

Reengineered epipodophyllotoxin

Abstract

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

Graphical abstract: Reengineered epipodophyllotoxin

Supplementary files

Article information

Article type
Communication
Submitted
14 Jul 2012
Accepted
29 Aug 2012
First published
17 Sep 2012

Chem. Commun., 2012,48, 10416-10418

Reengineered epipodophyllotoxin

I. V. Magedov, N. M. Evdokimov, M. Karki, A. S. Peretti, D. T. Lima, L. V. Frolova, M. R. Reisenauer, A. E. Romero, P. Tongwa, A. Fonari, J. Altig, S. Rogelj, M. Yu. Antipin, C. B. Shuster and A. Kornienko, Chem. Commun., 2012, 48, 10416 DOI: 10.1039/C2CC35044K

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