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Issue 79, 2012
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Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

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Abstract

We describe the design and synthesis of a non-peptidic β-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.

Graphical abstract: Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

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Publication details

The article was received on 04 Jul 2012, accepted on 26 Jul 2012 and first published on 26 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC34791A
Citation: Chem. Commun., 2012,48, 9834-9836
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    Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

    C. L. Sutherell, S. Thompson, R. T. W. Scott and A. D. Hamilton, Chem. Commun., 2012, 48, 9834
    DOI: 10.1039/C2CC34791A

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