Issue 76, 2012
From the journal:

Chemical Communications

Facile synthesis of colorimetric histone deacetylase substrates†

Alexander Dose,‡a   Jan Oliver Jost,‡a   Antje C. Spieß,b   Petra Henklein,c   Michael Beyermannd  and  Dirk Schwarzer*a  

* Corresponding authors

a Interfaculty Institute of Biochemistry, University of Tuebingen, Hoppe-Seyler-Str. 4, 72076 Tuebingen, Germany
E-mail: dirk.schwarzer@uni-tuebingen.de
Fax: +49-7071-29-4518
Tel: +49-7071-29-73344

b RWTH Aachen, Worringer Weg 1, 52056 Aachen, Germany

c Institut für Biochemie, Charité - Universitätsmedizin Berlin, Oudenarder Straße 16, 13347 Berlin, Germany

d Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany

Abstract

Here we report a simple procedure for generating colorimetric histone deacetylase (HDAC) substrates by solid-phase peptide synthesis based on racemization-free couplings of amino acid chlorides. We demonstrate the applicability of these substrates in HDAC assays.

Graphical abstract: Facile synthesis of colorimetric histone deacetylase substrates

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Article information

DOI
https://doi.org/10.1039/C2CC34422J
Article type
Communication
Submitted
20 Jun 2012
Accepted
03 Aug 2012
First published
06 Aug 2012

Chem. Commun., 2012,48, 9525-9527

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Facile synthesis of colorimetric histone deacetylase substrates

A. Dose, J. O. Jost, A. C. Spieß, P. Henklein, M. Beyermann and D. Schwarzer, Chem. Commun., 2012, 48, 9525 DOI: 10.1039/C2CC34422J

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