Issue 68, 2012

Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

Abstract

Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb–Eu complexes.

Graphical abstract: Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

Supplementary files

Article information

Article type
Communication
Submitted
14 Jun 2012
Accepted
10 Jul 2012
First published
11 Jul 2012

Chem. Commun., 2012,48, 8520-8522

Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

D. G. Smith, B. K. McMahon, R. Pal and D. Parker, Chem. Commun., 2012, 48, 8520 DOI: 10.1039/C2CC34267G

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